![]() Therefore, it is crucial to detect midperipheral or far peripheral capillary non-perfusion in DR patients, especially in the early stages of the disease.įA, a dye-based angiography, is widely recognized as an essential tool in evaluating the severity of DR ( 15). Midperipheral capillary non-perfusion has been shown to be the most common type in early stage DR and the extent of capillary non-perfusion is more pronounced in eyes with retinal and optic disc neovascularization ( 13, 14). Currently, retinal capillary non-perfusion is readily demonstrated by fluorescein angiography (FA). VEGF promotes both angiogenic responses and vascular permeability ( 11, 12). Capillary non-perfusion impairs the delivery of nutrients to the neuroglial tissues in the retina, resulting in hypoxia and the expression of vascular endothelial growth factor (VEGF). It is characterized by microaneurysms (MAs), capillary non-perfusion, and ischemia within the retina ( 2- 5) that may lead to several complications, such as diabetic macular edema (DME), diabetic macular ischemia, and neovascularization of the retina ( 6- 10). Accepted for publication Sep 12, 2018.ĭiabetic retinopathy (DR) is the leading cause of blindness in the United States for patients aged 20–64 years ( 1). Keywords: Diabetic retinopathy (DR) field of view (FOV) non-perfusion optical coherence tomography angiography (OCTA) swept source OCTA vessel density Vessel density and non-perfusion maps were used to measure progressive capillary non-perfusion and regression of neovascularization between visits.Ĭonclusions: UW-OCTA provides approximately 100-degree OCTA images of the fundus comparable to that of wide-angle fundus photography, and may be more applicable in conditions such as DR which affect the peripheral retina in contrast to standard OCTA. Neovascularization complexes were clearly detected in the two patients with active PDR. UW-OCTA images provided more detailed visualization of vascular networks compared to 50-degree fluorescein angiography (FA) and showed higher burden of pathology in the retinal periphery that was not captured by typical OCTA. Results: Three proliferative DR patients were included in the study. Vessel density and non-perfusion area maps were calculated based on the UW-OCTA images. They were treated at the clinician’s discretion. DR patients were scanned at baseline and follow-up. Typical OCTA images with a FOV of 3×3, 6×6 and 12×12 mm 2 were obtained for comparison. A montage scanning protocol was used to capture a 100-degree field of view (FOV) using a 4×4 grid of sixteen total individual 6×6 mm 2 scans. Methods: UW-OCTA was implemented on a 1,060 nm swept source (SS) OCTA engine running at 100 kHz A-line rate with a motion tracking mechanism. Policy of Dealing with Allegations of Research Misconductīackground: To implement an ultra-wide optical coherence tomography angiography imaging (UW-OCTA) modality in eyes with diabetic retinopathy (DR) with the aim of quantifying the burden of microvascular disease at baseline and subsequent clinic visits.Policy of Screening for Plagiarism Process.
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